venerdì 2 marzo 2007

Circoncisione e infezione da HIV



Due studi condotti in Kenia e Uganda dal NIH sono stati interrotti per i precoci risultati positivi. I due studi valutavano l'efficacia della circoncisione nella prevenzione dell'infezione da HIV, In entrambi i trials dei volontari sani, HIV negativi, venivano arruolati nello studio e randomizzati per essere sottoposti alla circoncisione o per far parte de gruppo controllo. I risultati di una prima analisi circa un anno e mezzo dopo l'inizio dello studio mostravano una impressionante riduzione dell'incidenza di infezione da HIV nel gruppo sottoposto a circoncisione (53% in meno rispetto al gruppo di controllo in Kenia, 48% in Uganda !!)
Questo il link alla press release del NIH. Più in basso nella sezione in Inglese una breve nota di Anthony Fauci.

At a December 13, 2006, press conference, the NIH presented data from two studies - conducted in Kenya and Uganda - on adult male circumcision for the prevention of HIV infection (see press release). In both trials, healthy HIV-negative men were randomized to receive circumcision immediately or to wait 2 years. All men received HIV prevention counseling, and follow-up was extensive.
Both trials met enrollment targets by September 2005 and were supposed to continue through mid-2007. However, the results of an interim analysis by the Data and Safety Monitoring Board on December 12, 2006, were impressive enough to prompt early termination, and all men in the control groups are now being offered immediate circumcision. Among nearly 2800 volunteers in the Kenyan trial, HIV incidence was 53% lower in those who received circumcision than in controls. Among nearly 5000 volunteers in the Ugandan trial, HIV incidence was 48% lower in those who received circumcision.
NIAID Director Anthony S. Fauci stated in a press release: "While the initial benefit will be fewer HIV infections in men, ultimately adult male circumcision could lead to fewer infections in women in those areas of the world where HIV is spread primarily through heterosexual intercourse."
(from Journal watch)

Nessun commento: