lunedì 21 maggio 2007

Aspirina nella prevenzione cardiovascolare: quale dosaggio

Aspirin Dose for the Prevention of Cardiovascular Disease
A Systematic Review
Charles L. Campbell, MD; Susan Smyth, MD, PhD; Gilles Montalescot, MD, PhD; Steven R. Steinhubl, MD

Una review pubblicata su JAMA esamina il rapporto rischio beneficio dell'aspirina nella terapia antiaggregante come prevenzione di eventi cardiovascolari. Le conclusioni sono per un dosaggio compreso tra 75 e 81 mg.

Review Finds Lower Dose Best for Prophylactic Aspirin

Aspirin doses should not exceed 75 to 81 mg/day when the drug is used to prevent cardiovascular disease, a JAMA systematic review finds.

The authors sought the balance point between aspirin's cardioprotective effects and the known complications of the drug, which they say is taken preventively by over one-third of U.S. adults. Their literature review leads them to conclude that, although multiple studies confirm the increasing incidence of adverse effects with increasing dosage, "no such dose relationship has been identified for efficacy."

"Currently, the clinical data are most supportive of a 75- or 81-mg daily dose," they write.

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