martedì 26 giugno 2007

Rischio cardiovascolare e alterato metabolismo del glucosio

Un interessante lavoro pubblicato su Circulation evidenzia come non solo il diabete conclamato ma anche una ridotta tolleranza al glucosio o una glicemia a digiuno alterata sia collegati ad un aumentato rischio cardiovascolare. Lo studio ha coinvolto 10.000 pazienti sia diabetici che non e nel follow up (durato 5 anni) si è evidenziata una aumentata mortalità nei gruppi sia con diabete che con una condizione di "prediabete". Ancora una volta un messaggio che sembra stimolare ad una maggiore aggressività nel controllo di questi parametri metabolici.

Risk of Cardiovascular and All-Cause Mortality in Individuals With Diabetes Mellitus, Impaired Fasting Glucose, and Impaired Glucose Tolerance. The Australian Diabetes, Obesity, and Lifestyle Study (AusDiab)
Elizabeth L.M. Barr MPH*, et al.
Circulation 2007, doi:10.1161/CIRCULATIONAHA.106.685628

Risks for all-cause and cardiovascular-related deaths increase not only with diabetes, but also with milder elevations in glucose, a study released early by Circulation reports.

Researchers evaluated the mortality risks associated with diabetes and prediabetic states in an Australian cohort. Among some 10,000 adults examined at baseline and followed for a median of about 5 years, all-cause mortality was higher among those with known diabetes, impaired fasting glucose, or impaired glucose tolerance than among those with normal glucose tolerance. (The mortality risk was doubled in diabetics -- and 50% to 60% higher in those with "prediabetes" -- compared with those with normal glucose tolerance.)

Cardiovascular mortality was increased among those with diabetes or impaired fasting glucose, but not among those with impaired glucose tolerance.

According to the authors, these findings suggest that preventive strategies should also target "people with milder forms of abnormal glucose metabolism."

2 commenti:

Anonimo ha detto...

imparato molto

Anonimo ha detto...

leggere l'intero blog, pretty good